Article
[Genome analyses for precancerous lesions in the gastrointestinal tract].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Mar 2000
Sowa M, Nakata B
Abstract excerpt
We herein summarize the reports on genetic changes in precancerous lesions in the gastrointestinal tract. It has been reported that with esophageal lesions such as dysplasia and Barrett's esophagus there is a high frequency of p53 mutations. Among gastric lesions, some cases of chronic atrophic gastritis have been shown to harbor K-ras mutations. p53 and APC mutations in intestinal metaplasia have also been...
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