Article
Long-term Helicobacter pylori infection in Japanese monkeys induces atrophic gastritis and accumulation of mutations in the p53 tumor suppressor gene.
Helicobacter - 1 Jun 2002
Oda Touta, Murakami Kazunari, Nishizono Akira, Kodama Masaaki, Nasu Masaru, Fujioka Toshio
Abstract excerpt
BACKGROUND: Helicobacter pylori is accepted as a definite human gastric carcinogen from an epidemiological point of view despite insufficient experimental data. Although we previously showed that the number of p53 immunopositive cells in the atrophic gastric mucosa of H. pylori-infected Japanese monkeys gradually increased over time, data on p53 gene mutations were not obtained in that study. To obtain direct...
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