Article
The apolipoprotein E/CI/CII gene cluster and late-onset Alzheimer disease.
American journal of human genetics - 1 Apr 1994
Yu C E, Payami H, Olson J M, Boehnke M, Wijsman E M, Orr H T, Kukull W A, Goddard K A, Nemens E, White J A
Abstract excerpt
The chromosome 19 apolipoprotein E/CI/CII gene cluster was examined for evidence of linkage to a familial Alzheimer disease (FAD) locus. The family groups studied were Volga German (VG), early-onset non-VG (ENVG; mean age at onset < 60 years), and late-onset families. A genetic association was observed between apolipoprotein E (ApoE) allele epsilon 4 and FAD in late-onset families; the epsilon 4 allele frequency...
Topics
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoprotein C-I
- Apolipoprotein C-II
- Apolipoproteins C
- Apolipoproteins E
- Chromosomes, Human, Pair 19