Article
Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium?
Annals of neurology - 1 Jul 1994
Tsuda T, Lopez R, Rogaeva E A, Freedman M, Rogaev E, Drachman D, Pollen D, Haines J, Liang Y, McLachlan D R
Abstract excerpt
Allele frequencies for polymorphisms in the apolipoprotein E and the apolipoprotein CII genes were determined in subjects of Ashkenazi Jewish origin with late-onset Alzheimer's disease and in unaffected control subjects from the same ethnic group. A significant association was observed between late-onset Alzheimer's disease and the epsilon 4 (112Cys-->Arg) allele of apolipoprotein E; however, no association was...
Topics
- Aged
- Alleles
- Alzheimer Disease
- Apolipoprotein C-II
- Apolipoproteins C
- Apolipoproteins E
- Female
- Gene Frequency
- Humans
- Jews
- Linkage Disequilibrium