A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping or DNA sequencing. V. Analysis of case/control sampling designs: Alzheimer's disease and the apoprotein E locus.

doi:10.1093/genetics/140.1.403

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Article

A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping or DNA sequencing. V. Analysis of case/control sampling designs: Alzheimer's disease and the apoprotein E locus.

Genetics - 1 May 1995

Templeton A R

Abstract excerpt

Present-day associations between haplotypes at a candidate locus and phenotypes exist when phenotypically important mutations occurred at some point during the evolution of the current array of genetic variation. A cladistic statistical design can be defined that focuses power by using the evolutionary history of the candidate DNA region. This paper shows how cladistic methodology is used for the analysis of...

Topics

Age of Onset
Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoprotein C-I
Apolipoprotein C-II
Apolipoproteins C
Apolipoproteins E
Case-Control Studies
Chi-Square Distribution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

France

Genetic Variation

Haplotypes

Humans

Middle Aged

Mutation

Phenotype

Source

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Identifiers

PMID: 7635303
DOI: 10.1093/genetics/140.1.403
PMCID: PMC1206565

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7635303-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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