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Article

Genetic association and linkage analysis of the apolipoprotein CII locus and familial Alzheimer's disease.

Annals of neurology - 1 Feb 1992

Schellenberg G D, Boehnke M, Wijsman E M, Moore D K, Martin G M, Bird T D

Abstract excerpt

We previously reported a genetic association between the 3.5 kb (F) Taq I restriction fragment length polymorphism allele of the apolipoprotein CII gene on chromosome 19 and familial Alzheimer's disease. Here, we report an additional analysis of this association performed on an expanded and better defined data set of 23 families with familial Alzheimer's disease. The F allele frequency in affected family members...

Topics

Alleles
Alzheimer Disease
Apolipoprotein C-II
Apolipoproteins C
Gene Frequency
Genotype
Humans
Lod Score
Polymorphism, Restriction Fragment Length
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1349467
DOI: 10.1002/ana.410310214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1349467-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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