Article
M protein of subacute sclerosing panencephalitis virus, synergistically with the F protein, plays a crucial role in viral neuropathogenicity.
The Journal of general virology - 1 Oct 2021
Satoh Yuto, Higuchi Kurara, Nishikawa Daichi, Wakimoto Hiroshi, Konami Miho, Sakamoto Kento, Kitagawa Yoshinori, Gotoh Bin, Jiang Da-Peng, Hotta Hak, Itoh Masae
Abstract excerpt
Subacute sclerosing panencephalitis (SSPE) is a rare fatal neurodegenerative disease caused by a measles virus (MV) variant, SSPE virus, that accumulates mutations during long-term persistent infection of the central nervous system (CNS). Clusters of mutations identified around the matrix (M) protein in many SSPE viruses suppress productive infectious particle release and accelerate cell-cell fusion, which are...
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