Article
Sp1 is essential for both enhancer-mediated and basal activation of the TATA-less human adenosine deaminase promoter.
Nucleic acids research - 25 Feb 1994
Dusing M R, Wiginton D A
Abstract excerpt
Tissue-specific expression of the human adenosine deaminase (ADA) gene is mediated by transcriptional activation over a thousand-fold range. Cis-regulatory regions responsible for high and basal levels of activation include an enhancer and the proximal promoter region. While analyses of the T-cel...
Topics
- Adenosine Deaminase
- Base Sequence
- Electrophoresis, Polyacrylamide Gel
- Enhancer Elements, Genetic
- Humans
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Sequence Deletion
- Sp1 Transcription Factor
- TATA Box
- Transcriptional Activation