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Article

HGSNAT has a TATA-less promoter with multiple starts of transcription.

Gene - 30 Oct 2016

Richtrova Eva, Mrazova Lenka S, Musalkova Dita, Luksan Ondrej, Stolnaya Larisa, Minks Jakub, Lukas Jan, Dvorakova Lenka, Jirsa Milan, Hrebicek Martin

Abstract excerpt

Acetyl-CoA:α-glucosaminide N-acetyltransferase (N-acetyltransferase) is a lysosomal membrane enzyme that catalyzes a key step in the lysosomal degradation of heparan sulfate. Its deficiency causes Sanfilippo syndrome type IIIC (Mucopolysaccharidosis type IIIC, MPS IIIC). Here we characterize the promoter region of HGSNAT, the gene encoding N-acetyltransferase, which is located in the pericentromeric region of...

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Identifiers

PMID: 27452122
DOI: 10.1016/j.gene.2016.07.051

Genes

HGSNAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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