Article
Expression of the human Hand1 gene in trophoblastic cells is transcriptionally regulated by activating and repressing specificity protein (Sp)-elements.
Gene - 2 Jan 2003
Vasicek Richard, Meinhardt Gudrun, Haidweger Eva, Rotheneder Hans, Husslein Peter, Knöfler Martin
Abstract excerpt
The tissue-specific basic helix-loop-helix protein Hand1 is essential for the formation of trophoblast giant cells of the murine placenta. In humans, Hand1 is detectable in trophoblastic tumour cells suggesting an equivalent role in trophoblast differentiation. To understand its mode of expression we have cloned and characterized the human Hand1 gene promoter. Primer extension analyses suggest that transcription...
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