Article
Two domains of the tolloid protein contribute to its unusual genetic interaction with decapentaplegic.
Developmental biology - 1 Mar 1994
Childs S R, O'Connor M B
Abstract excerpt
The zygotic dorsal-ventral patterning gene tolloid (tld) exhibits a complex structure consisting of an N-terminal domain with sequence similarity to the astacin family of metalloproteases and a C-terminal domain composed of two EGF-like repeats and five copies of the CUB repeat which was first found in human complement proteins C1r and C1s. The overall structure of TLD is similar to the human bone morphogenetic...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Binding Sites
- Cloning, Molecular
- Drosophila
- Drosophila Proteins
- Endopeptidases
- Insect Hormones
- Molecular Sequence Data
- Morphogenesis
- Mutation