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Article

Use of Bmp1/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1/tolloid-like metalloproteinases.

Molecular and cellular biology - 1 Jul 2003

Pappano William N, Steiglitz Barry M, Scott Ian C, Keene Douglas R, Greenspan Daniel S

Abstract excerpt

Bone morphogenetic protein 1 (BMP-1) and mammalian Tolloid (mTLD), two proteinases encoded by Bmp1, provide procollagen C-proteinase (pCP) activity that converts procollagens I to III into the major fibrous components of mammalian extracellular matrix (ECM). Yet, although Bmp1(-/-) mice have aberrant collagen fibrils, they have residual pCP activity, indicative of genetic redundancy. Mammals possess two...

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Identifiers

PMID: 12808086
DOI: 10.1128/MCB.23.13.4428-4438.2003
PMCID: PMC164836

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Source receipt: pubmed, retrieved 7 Sept 2026.

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