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Article

Mutational analysis of the Drosophila tolloid gene, a human BMP-1 homolog.

Development (Cambridge, England) - 1 Apr 1994

Finelli A L, Bossie C A, Xie T, Padgett R W

Abstract excerpt

Seven zygotically active genes have been identified in Drosophila that determine the fate of dorsal cells in the developing embryo. decapentaplegic (dpp), a member of the transforming growth factor-beta (TGF-beta) family, appears to play the central role in dorsal ectoderm formation, as mutations in this gene confer the most severe mutant phenotype of this group of genes. dpp's activity is modulated by tolloid,...

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Identifiers

PMID: 7600963
DOI: 10.1242/dev.120.4.861

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Mutational analysis of the Drosophila tolloid gene, a human BMP-1 homolog.PMID 7600963Read ↗

Two domains of the tolloid protein contribute to its unusual genetic interaction with decapentaplegic.Semantic proximity Read ↗

The tolkin gene is a tolloid/BMP-1 homologue that is essential for Drosophila development.Semantic proximity Read ↗

Localized enhancement and repression of the activity of the TGF-beta family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo.Semantic proximity Read ↗

Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.Semantic proximity Read ↗

The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart.Semantic proximity Read ↗

Molecular lesions associated with alleles of decapentaplegic identify residues necessary for TGF-beta/BMP cell signaling in Drosophila melanogaster.Semantic proximity Read ↗

Deletion of epidermal growth factor-like domains converts mammalian tolloid into a chordinase and effective procollagen C-proteinase.Semantic proximity Read ↗

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.Semantic proximity Read ↗

Use of Bmp1/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1/tolloid-like metalloproteinases.Semantic proximity Read ↗

Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.Semantic proximity Read ↗

Molecular organization of the decapentaplegic gene in Drosophila melanogaster.Semantic proximity Read ↗

A screen for modifiers of decapentaplegic mutant phenotypes identifies lilliputian, the only member of the Fragile-X/Burkitt's Lymphoma family of transcription factors in Drosophila melanogaster.Semantic proximity Read ↗

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