Article
Molecular lesions associated with alleles of decapentaplegic identify residues necessary for TGF-beta/BMP cell signaling in Drosophila melanogaster.
Genetics - 1 Feb 1996
Wharton K, Ray R P, Findley S D, Duncan H E, Gelbart W M
Abstract excerpt
We have identified the molecular lesions associated with six point mutations in the Drosophila TGF-beta homologue decapentaplegic (dpp). The sites of these mutations define residues within both the pro and ligand regions that are essential for dpp function in vivo. While all of these mutations af...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Gene Expression
- Genetic Complementation Test
- Insect Proteins
- Male
- Molecular Sequence Data
- Point Mutation
- Signal Transduction
- Temperature
- Transforming Growth Factor beta