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Article

Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts

1 May 1993

Abstract excerpt

The state of cellular senescence is characterised by an irreversible arrest in the G1 phase of the cell cycle. It has previously been shown that three cell cycle genes, cyclin A, cyclin B and cdc2, are not expressed in senescent human fibroblasts. All three gene products have functions after S-phase entry, so that their suppression cannot explain the irreversible G1 arrest. Here, we report that the abundance of...

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PMID: 8360268
DOI: 10.1242/jcs.105.1.123

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