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Article

DNA methyltransferase inhibition in normal human fibroblasts induces a p21-dependent cell cycle withdrawal.

The Journal of biological chemistry - 1 Jun 2001

Young J I, Smith J R

Abstract excerpt

Maintenance of methylation patterns in the mammalian genome by DNA (cytosine-5) methyltransferases (DNAMeTase) is required for normal cell and tissue function. Inhibition of DNAMeTase in cultured cells induces the expression of p21, a cyclin-dependent kinase (Cdk) inhibitor critical for cells to enter replicative senescence. We investigated the effects of DNAMeTase inhibition in normal human fibroblasts and found...

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PMID: 11259405
DOI: 10.1074/jbc.M009470200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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