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Role of Host Factors on the Regulation of Tat-Mediated HIV-1 Transcription

13 Oct 2017

Abstract excerpt

BACKGROUND: The viral transactivator Tat protein is a key modulator of HIV-1 replication, as it regulates transcriptional elongation from the integrated proviral genome. Tat recruits the human transcription elongation factor b, and other host proteins, such as the super elongation complex, to activate the cellular RNA polymerase II, normally stalled shortly after transcription initiation at the HIV promoter. By...

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PMID: 28641539
DOI: 10.2174/1381612823666170622104355

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