NIP domain prevents N-type inactivation in voltage-gated potassium channels.

doi:10.1038/34916

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Article

NIP domain prevents N-type inactivation in voltage-gated potassium channels.

Nature - 22 Jan 1998

Roeper J, Sewing S, Zhang Y, Sommer T, Wanner S G, Pongs O

Abstract excerpt

Shaker-related voltage-gated K+ (Kv) channels are assembled from ion-conducting K(v)alpha subunits, which are integral membrane proteins, and auxiliary K(v)beta subunits. This leads to the formation of highly diverse heteromultimeric Kv channels that mediate outward currents with a wide range of...

Topics

Amino Acid Sequence
Animals
Binding Sites
CHO Cells
Cloning, Molecular
Cricetinae
Electrochemistry
Escherichia coli
Ion Channel Gating
Molecular Sequence Data
Mutation
Potassium Channel Blockers
Potassium Channels
Recombinant Fusion Proteins
Shaker Superfamily of Potassium Channels

Source

Open in PubMed

Identifiers

PMID: 9450755
DOI: 10.1038/34916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9450755-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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