Article
Molecular studies of voltage-gated potassium channels.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 1990
Isacoff E, Papazian D, Timpe L, Jan Y N, Jan L Y
Abstract excerpt
The cloning and characterization of the voltage-activated Shaker potassium channel gene in Drosophila have led to the identification of structural elements involved in potassium channel gating. As found for the voltage-activated sodium channel, the S4 segment, located in the conserved core of the protein, plays a central role in voltage-dependent activation. Potassium channels appear to be formed by the assembly...
Topics
- Animals
- Cloning, Molecular
- DNA, Recombinant
- Drosophila
- Electrophysiology
- Ion Channel Gating
- Molecular Biology
- Mutation
- Phenotype
- Potassium Channels