Impairment of natural killer functions by interleukin 6 increases lymphoblastoid cell tumorigenicity in athymic mice.

doi:10.1172/JCI115283

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Article

Impairment of natural killer functions by interleukin 6 increases lymphoblastoid cell tumorigenicity in athymic mice.

The Journal of clinical investigation - 1 Jul 1991

Tanner J, Tosato G

Abstract excerpt

Expression of the human IL-6 gene in EBV-immortalized normal human B lymphocytes following retroviral-mediated transduction rendered these cells highly tumorigenic in athymic mice. The tumors were lymphomas composed of the originally inoculated human lymphoblastoid cells. Co-injection of IL-6 exp...

Topics

Animals
B-Lymphocytes
Cell Line
Cell Transformation, Viral
Female
HLA-DR Antigens
Herpesvirus 4, Human
Interleukin-6
Killer Cells, Natural
Lymphoma
Mice
Mice, Nude
Neoplasm Transplantation
Phenotype
Transfection

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