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Article

Metastatic lesions with and without interleukin-18-dependent genes in advanced-stage melanoma patients.

The American journal of pathology - 1 Jul 2013

Crende Olatz, Sabatino Marianna, Valcárcel María, Carrascal Teresa, Riestra Pia, López-Guerrero Jose A, Nagore Eduardo, Mandruzzato Susanna, Wang Ena, Marincola Francesco M, Vidal-Vanaclocha Fernando

Abstract excerpt

IL-18 is an immune-stimulating cytokine that promotes experimental melanoma metastasis via vascular endothelial growth factor (VEGF)-induced very late antigen (VLA)-4. We studied genes associated with the ability of melanoma cells to allow metastasis under IL-18 effects, and we verified their expression in metastatic lesions from patients with melanoma. Human melanoma cell lines with and without the IL-18...

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Identifiers

PMID: 23707237
DOI: 10.1016/j.ajpath.2013.03.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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