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Article

Interleukin-6 gene ablation in a transgenic mouse model of malignant skin melanoma.

The American journal of pathology - 1 Mar 2005

von Felbert Verena, Córdoba Francisco, Weissenberger Jakob, Vallan Claudio, Kato Masashi, Nakashima Izumi, Braathen Lasse Roger, Weis Joachim

Abstract excerpt

Interleukin (IL)-6 is a pleiotropic cytokine that has been shown to inhibit the growth of early stage and to promote the proliferation of advanced stage melanoma cells in vitro. In patients with metastasizing melanomas, highly increased IL-6 blood levels correlate with a poor response to chemotherapy and a worse overall prognosis, suggesting that IL-6 promotes melanoma progression in vivo. Here, we analyzed the...

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Identifiers

PMID: 15743795
DOI: 10.1016/S0002-9440(10)62304-8
PMCID: PMC1602365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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