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Article

Pharmacologic suppression of JAK1/2 by JAK1/2 inhibitor AZD1480 potently inhibits IL-6-induced experimental prostate cancer metastases formation.

Molecular cancer therapeutics - 1 May 2014

Gu Lei, Talati Pooja, Vogiatzi Paraskevi, Romero-Weaver Ana L, Abdulghani Junaid, Liao Zhiyong, Leiby Benjamin, Hoang David T, Mirtti Tuomas, Alanen Kalle, Zinda Michael, Huszar Dennis, Nevalainen Marja T

Abstract excerpt

Metastatic prostate cancer is lethal and lacks effective strategies for prevention or treatment, requiring novel therapeutic approaches. Interleukin-6 (IL-6) is a cytokine that has been linked with prostate cancer pathogenesis by multiple studies. However, the direct functional roles of IL-6 in prostate cancer growth and progression have been unclear. In the present study, we show that IL-6 is produced in distant...

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Identifiers

PMID: 24577942
DOI: 10.1158/1535-7163.MCT-13-0605
PMCID: PMC4013199

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JAK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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