Article
Evidence for selection against human lung cancers bearing p53 missense mutations which occur within the HLA A*0201 peptide consensus motif.
Cancer research - 1 Mar 1994
Wiedenfeld E A, Fernandez-Viña M, Berzofsky J A, Carbone D P
Abstract excerpt
Short peptide fragments of intracellular proteins that fit a defined sequence motif bind to the most common human major histocompatibility complex class I molecule, HLA A*0201, and mediate killing by cytotoxic T-cells [D.F. Hunt et al., Science (Washington DC), 255: 1261-1263, 1992; K. Falk et al., Nature (Lond.), 351: 290-296, 1991]. The existence of such a motif allows prediction of whether novel peptides...
Topics
- Alleles
- DNA, Neoplasm
- Genes, p53
- HLA-A Antigens
- Humans
- Lung Neoplasms
- Mutation
- Peptide Fragments
- Tumor Cells, Cultured