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Article

Spontaneous human squamous cell carcinomas are killed by a human cytotoxic T lymphocyte clone recognizing a wild-type p53-derived peptide.

Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 1996

Röpke M, Hald J, Guldberg P, Zeuthen J, Nørgaard L, Fugger L, Svejgaard A, Van der Burg S, Nijman H W, Melief C J, Claesson M H

Abstract excerpt

A cytotoxic T lymphocyte (CTL) clone generated in vitro from the peripheral blood of a healthy HLA-A2-positive individual against a synthetic p53 protein-derived wild-type peptide (L9V) was shown to kill squamous carcinoma cell lines derived from two head and neck carcinomas, which expressed mutant p53 genes, in a L9V/HLA-A2 specific and restricted fashion. Thus, the normal tolerance against endogenously...

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Share to Carcinoma, Squamous Cell
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to HLA-A2 Antigen

Share to Mutation

Share to T-Lymphocytes, Cytotoxic

Share to Tumor Cells, Cultured

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 8962118
DOI: 10.1073/pnas.93.25.14704
PMCID: PMC26199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Spontaneous human squamous cell carcinomas are killed by a human cytotoxic T lymphocyte clone recognizing a wild-type p53-derived peptide.PMID 8962118Read ↗

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