Article
Spontaneous human squamous cell carcinomas are killed by a human cytotoxic T lymphocyte clone recognizing a wild-type p53-derived peptide.
Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 1996
Röpke M, Hald J, Guldberg P, Zeuthen J, Nørgaard L, Fugger L, Svejgaard A, Van der Burg S, Nijman H W, Melief C J, Claesson M H
Abstract excerpt
A cytotoxic T lymphocyte (CTL) clone generated in vitro from the peripheral blood of a healthy HLA-A2-positive individual against a synthetic p53 protein-derived wild-type peptide (L9V) was shown to kill squamous carcinoma cell lines derived from two head and neck carcinomas, which expressed muta...
Topics
- Carcinoma, Squamous Cell
- Cytotoxicity, Immunologic
- HLA-A2 Antigen
- Head and Neck Neoplasms
- Humans
- Mutation
- T-Lymphocytes, Cytotoxic
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53