Allelic frequency of a p53 polymorphism in human lung cancer.

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Article

Allelic frequency of a p53 polymorphism in human lung cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2000

Weston A, Perrin L S, Forrester K, Hoover R N, Trump B F, Harris C C, Caporaso N E

Abstract excerpt

p53 is a tumor suppressor gene that is mutated in diverse tumor types. Here we report the frequencies of common polymorphic variants at codon 72 of the p53 gene in germline DNA of lung cancer cases and controls as determined by a polymerase chain reaction strategy. The observed allelic distribution was found to be significantly different between African-Americans and Caucasians in this U.S. population. The...

Topics

Adenocarcinoma
Alleles
Arginine
Black People
Carcinoma
Case-Control Studies
Codon
DNA, Neoplasm
Exons
Gene Frequency
Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Heterozygote

Homozygote

Humans

Lung Diseases, Obstructive

Lung Neoplasms

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 1302561

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1302561-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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