Article
Relationship of p53 overexpression on cancers and recognition by anti-p53 T cell receptor-transduced T cells.
Human gene therapy - 1 Nov 2008
Theoret Marc R, Cohen Cyrille J, Nahvi Azam V, Ngo Lien T, Suri Kimberly B, Powell Daniel J, Dudley Mark E, Morgan Richard A, Rosenberg Steven A
Abstract excerpt
Tumor suppressor p53 is reported to be an attractive immunotherapy target because it is mutated in approximately half of human cancers, resulting in inactivation and often an accumulation of the protein in the tumor cells. Only low amounts of protein are detectable in normal tissues. The differential display of antigen in normal versus tumor tissues has been reported to create an opportunity to target p53 by...
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