Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A HLA-A2 restricted human CTL line recognizes a novel tumor cell expressed p53 epitope.

International journal of cancer - 1 Jun 2002

Würtzen Peter A, Claesson Mogens H

Abstract excerpt

A p53 peptide-specific CTL line was generated through stimulation with autologous monocyte-derived dendritic cells (DC) pulsed with wild-type HLA-A2 binding p53 derived peptides. A p53 peptide-specific CD8(+) CTL line was established from a healthy HLA-A2 positive donor. The CTL line was characterized with respect to specificity, affinity and killing of cell lines derived from p53 mutated spontaneous tumors. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8 Antigens
Share to Dose-Response Relationship, Drug
Share to Epitopes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to HLA-A2 Antigen

Share to Peptides

Share to T-Lymphocytes, Cytotoxic

Share to Up-Regulation

Source

Identifiers

PMID: 11992547
DOI: 10.1002/ijc.10375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A HLA-A2 restricted human CTL line recognizes a novel tumor cell expressed p53 epitope.PMID 11992547Read ↗

Specific killing of P53 mutated tumor cell lines by a cross-reactive human HLA-A2-restricted P53-specific CTL line.Semantic proximity Read ↗

Cytotoxic T-lymphocyte clones, established by stimulation with the HLA-A2 binding p5365-73 wild type peptide loaded on dendritic cells In vitro, specifically recognize and lyse HLA-A2 tumour cells overexpressing the p53 protein.Semantic proximity Read ↗

Generation of cytotoxic T cell responses to an HLA-A24 restricted epitope peptide derived from wild-type p53Semantic proximity Read ↗

Spontaneous human squamous cell carcinomas are killed by a human cytotoxic T lymphocyte clone recognizing a wild-type p53-derived peptide.Semantic proximity Read ↗

In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild-type p53.Semantic proximity Read ↗

Tolerance to p53 by A2.1-restricted Cytotoxic T LymphocytesSemantic proximity Read ↗

Identification of new epitopes from four different tumor-associated antigens: recognition of naturally processed epitopes correlates with HLA-A*0201-binding affinity.Semantic proximity Read ↗

Generation of T cells specific for the wild-type sequence p53(264-272) peptide in cancer patients: implications for immunoselection of epitope loss variants.Semantic proximity Read ↗

A wild-type sequence p53 peptide presented by HLA-A24 induces cytotoxic T lymphocytes that recognize squamous cell carcinomas of the head and neck.Semantic proximity Read ↗

Targeted tumor cell death induced by autologous tumor-specific T lymphocyte recognition of wild-type p53-derived peptides.Semantic proximity Read ↗

Wildtype p53-specific antibody and T-cell responses in cancer patients.Semantic proximity Read ↗

Recognition of Fresh Human Tumor by Human Peripheral Blood Lymphocytes Transduced with a Bicistronic Retroviral Vector Encoding a Murine Anti-p53 TCRSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.