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Article

Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma.

The American journal of pathology - 1 Aug 2002

Lee Jae-Hyuk, Abraham Susan C, Kim Hyun-Soo, Nam Jong-Hee, Choi Chan, Lee Min-Cheol, Park Chang-Soo, Juhng Sang-Woo, Rashid Asif, Hamilton Stanley R, Wu Tsung-Teh

Abstract excerpt

Gastric cancer is common among the world, but genetic mechanisms of gastric carcinogenesis are not well understood. Gastric polypoid adenomas and flat dysplasias are regarded as precursor lesions. However, a detailed molecular study of these lesions has not been done to determine their role as precancerous lesions. We investigated mutations of the APC, beta-catenin, and K-ras genes, and microsatellite instability...

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Identifiers

PMID: 12163385
DOI: 10.1016/S0002-9440(10)64216-2
PMCID: PMC1850731

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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