Article
Reverse dot blot probes for the screening of beta-thalassemia mutations in Asians and American blacks.
Human mutation - 1 Jan 1994
Cai S P, Wall J, Kan Y W, Chehab F F
Abstract excerpt
We have optimized a battery of reverse dot blot oligonucleotide probes for detecting the most common beta-globin gene mutations in Asians and American Blacks. These probes allow a high degree of coverage of mutant chromosomes in these two populations and are useful in mutation screening and prena...
Topics
- Asian People
- Base Sequence
- Black People
- DNA
- Genes
- Genetic Testing
- Genotype
- Globins
- Homozygote
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Oligonucleotide Probes
- Polymerase Chain Reaction
- Seroepidemiologic Studies
- United States
- beta-Thalassemia