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Article

A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin.

The Journal of biological chemistry - 26 Jul 2013

Bezold Kristina L, Shaffer Justin F, Khosa Jaskiran K, Hoye Elaine R, Harris Samantha P

Abstract excerpt

The M-domain is the major regulatory subunit of cardiac myosin-binding protein-C (cMyBP-C) that modulates actin and myosin interactions to influence muscle contraction. However, the precise mechanism(s) and the specific residues involved in mediating the functional effects of the M-domain are not fully understood. Positively charged residues adjacent to phosphorylation sites in the M-domain are thought to be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23782699
DOI: 10.1074/jbc.M113.474346
PMCID: PMC3724610

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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