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Article

Myosin regulatory light chain phosphorylation enhances cardiac β-myosin in vitro motility under load.

Archives of biochemistry and biophysics - 15 Aug 2015

Karabina Anastasia, Kazmierczak Katarzyna, Szczesna-Cordary Danuta, Moore Jeffrey R

Abstract excerpt

Familial hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy and myofibrillar disarray, and often results in sudden cardiac death. Two HCM mutations, N47K and R58Q, are located in the myosin regulatory light chain (RLC). The RLC mechanically stabilizes the myosin lever arm, which is crucial to myosin's ability to transmit contractile force. The N47K and R58Q mutations have...

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Identifiers

PMID: 26116789
DOI: 10.1016/j.abb.2015.06.014
PMCID: PMC4790447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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