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Article

Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.

Oncogene - 1 Mar 1994

Kieser A, Weich H A, Brandner G, Marmé D, Kolch W

Abstract excerpt

Many tumor cells produce vascular endothelial growth factor (VEGF), which is thought to be a pivotal mediator of tumor neoangiogenesis. Expression of the VEGF gene can be induced by tumor promoting phorbol esters, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), which activate protein kinase C (PKC). Here we show that in transient transfection assays a mutated form of the murine p53 tumor suppressor gene...

Topics

3T3 Cells
Animals
Endothelial Growth Factors
Enzyme Activation
Genes, p53
Humans
Lymphokines
Mice
Mutation
Protein Kinase C
RNA, Messenger
Tetradecanoylphorbol Acetate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vascular Endothelial Growth Factor A

Vascular Endothelial Growth Factors

Source

Identifiers

PMID: 8108142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8108142-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.PMID 8108142Read ↗

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