Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53.

Nucleic acids research - 25 Sept 1995

Kunz C, Pebler S, Otte J, von der Ahe D

Abstract excerpt

The ability of p53 to activate or repress transcription suggests that its biological function as tumor suppressor is in part accomplished by regulating a number of genes including such required for inhibition of cell growth. We here give evidence that p53 also may regulate genes responsible for the proteolytic degradation of the extracellular matrix, which is considered a crucial feature for local invasion and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA
Share to Molecular Sequence Data

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Promoter Regions, Genetic

Share to Protein Conformation

Share to RNA, Messenger

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7479001
DOI: 10.1093/nar/23.18.3710
PMCID: PMC307270

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53.PMID 7479001Read ↗

Transcription regulation by mutant p53.Semantic proximity Read ↗

Localization of a mutant p53 response element on the tissue inhibitor of metalloproteinase-3 promoter: mutant p53 activities are distinct from wild-type.Semantic proximity Read ↗

Differential modulation of cellular and viral promoters by p73 and p53.Semantic proximity Read ↗

p53 Phosphorylation at serine 15 is required for transcriptional induction of the plasminogen activator inhibitor-1 (PAI-1) gene by the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine.Semantic proximity Read ↗

Wild type and mutant p53 differentially regulate the gene expression of human collagenase-3 (hMMP-13).Semantic proximity Read ↗

Inhibition of the putative tumor suppressor gene TIMP-3 by tumor-derived p53 mutants and wild type p53.Semantic proximity Read ↗

Activation of c- myc Gene Expression by Tumor-Derived p53 Mutants Requires a Discrete C-Terminal DomainSemantic proximity Read ↗

Repression of RNA Polymerase I Transcription by the Tumor Suppressor p53Semantic proximity Read ↗

p53 Down-regulates Human Matrix Metalloproteinase-1 (Collagenase-1) Gene ExpressionSemantic proximity Read ↗

Mutant human tumor suppressor p53 modulates the activation of mitogen-activated protein kinase and nuclear factor-kappaB, but not c-Jun N-terminal kinase and activated protein-1.Semantic proximity Read ↗

Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1.Semantic proximity Read ↗

The tumor suppressor protein p53 strongly alters human immunodeficiency virus type 1 replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.