Article
Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53.
Nucleic acids research - 25 Sept 1995
Kunz C, Pebler S, Otte J, von der Ahe D
Abstract excerpt
The ability of p53 to activate or repress transcription suggests that its biological function as tumor suppressor is in part accomplished by regulating a number of genes including such required for inhibition of cell growth. We here give evidence that p53 also may regulate genes responsible for t...
Topics
- Base Sequence
- DNA
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Humans
- Molecular Sequence Data
- Mutation
- Plasminogen Activator Inhibitor 1
- Plasminogen Activators
- Promoter Regions, Genetic
- Protein Conformation
- RNA, Messenger
- Repressor Proteins
- Temperature
- Tissue Plasminogen Activator
- Trans-Activators
- Transcription, Genetic
- Transcriptional Activation