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Article

Activation of the Interleukin-6 promoter by a dominant negative mutant of c-Jun.

Biochimica et biophysica acta - 28 May 2004

Faggioli Laura, Costanzo Chiara, Donadelli Massimo, Palmieri Marta

Abstract excerpt

The human IL-6 promoter contains multiple regulatory elements such as those binding transcription factors belonging to the NF-kappaB (-75/-63), C/EBP (-158/-145 and -87/-76) and AP-1 (-283/-277) families. Herein, we report that ectopic expression of c-Jun, C/EBPdelta, and the p65 subunit of NF-kappaB synergistically activates an IL-6 promoter construct containing only a TATA box and a kappaB binding site. These...

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Identifiers

PMID: 15158360
DOI: 10.1016/j.bbamcr.2004.03.001

Genes

EBP
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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