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Article

Association of a precore genomic variant of hepatitis B virus with fulminant hepatitis.

Hepatology (Baltimore, Md.) - 1 Aug 1991

Carman W F, Fagan E A, Hadziyannis S, Karayiannis P, Tassopoulos N C, Williams R, Thomas H C

Abstract excerpt

A variant of hepatitis B virus has been described recently in HBsAg+ Mediterranean patients who lack HBeAg and who have an unusual and severe form of chronic hepatitis. This variant is unable to produce HBeAg because of the presence of a novel translational stop codon at the end of the precore region of the genome. By direct sequencing of DNA, generated by the polymerase chain reaction, we have evaluated the...

Topics

Base Sequence
DNA, Viral
Genes, Viral
Genetic Variation
Hepatic Encephalopathy
Hepatitis
Hepatitis B virus
Humans
Polymerase Chain Reaction
Viral Core Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1860679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1860679-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Association of a precore genomic variant of hepatitis B virus with fulminant hepatitis.PMID 1860679Read ↗

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