Article
Enhanced replication of hepatitis B virus with frameshift in the precore region found in fulminant hepatitis patients.
The Journal of infectious diseases - 1 Oct 2011
Inoue Jun, Ueno Yoshiyuki, Wakui Yuta, Fukushima Koji, Kondo Yasuteru, Kakazu Eiji, Ninomiya Masashi, Niitsuma Hirofumi, Shimosegawa Tooru
Abstract excerpt
BACKGROUND: The genotype B of hepatitis B virus (HBV) was reported to associate with fulminant hepatitis (FH). We aimed to clarify the characteristics of HBV obtained from FH patients in an area of Japan where genotype B HBV is prevalent. METHODS: Using serum samples of 16 HBV-associated FH patients, partial HBV sequences were determined. The effects of HBV mutation/insertion/deletion were evaluated using an in...
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