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Article

Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses.

Journal of virology - 1 Mar 1994

Shimizu Y K, Hijikata M, Iwamoto A, Alter H J, Purcell R H, Yoshikura H

Abstract excerpt

We developed an in vitro assay for antibodies to hepatitis C virus (HCV) that bind to virions and prevent initiation of the replication cycle in susceptible cells in vitro. These antibodies therefore appear to be capable of neutralizing the virus. Using this assay and a standard inoculum of HCV of known infectivity, we have measured the antibody in serial serum samples obtained from the same chronically infected...

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Identifiers

PMID: 8107212
DOI: 10.1128/JVI.68.3.1494-1500.1994
PMCID: PMC236605

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Source receipt: pubmed, retrieved 7 Sept 2026.

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