Article
Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses.
Journal of virology - 1 Mar 1994
Shimizu Y K, Hijikata M, Iwamoto A, Alter H J, Purcell R H, Yoshikura H
Abstract excerpt
We developed an in vitro assay for antibodies to hepatitis C virus (HCV) that bind to virions and prevent initiation of the replication cycle in susceptible cells in vitro. These antibodies therefore appear to be capable of neutralizing the virus. Using this assay and a standard inoculum of HCV of known infectivity, we have measured the antibody in serial serum samples obtained from the same chronically infected...
Topics
- Cell Line
- Genetic Variation
- Hepacivirus
- Hepatitis Antibodies
- Hepatitis C
- Hepatitis, Chronic
- Humans
- Mutation
- Neutralization Tests
- Polymerase Chain Reaction
- Precipitin Tests