Article
Evidence for cross-genotype neutralization of hepatitis C virus pseudo-particles and enhancement of infectivity by apolipoprotein C1.
Proceedings of the National Academy of Sciences of the United States of America - 22 Mar 2005
Meunier Jean-Christophe, Engle Ronald E, Faulk Kristina, Zhao Ming, Bartosch Birke, Alter Harvey, Emerson Suzanne U, Cosset Francois-Loic, Purcell Robert H, Bukh Jens
Abstract excerpt
The lack of a cell culture system to support hepatitis C virus (HCV) replication has hampered studies of this frequent cause of chronic liver disease. However, pseudotyped retroviral particles (pp) bearing the HCV envelope glycoproteins have provided a different approach to HCV studies. We used genotype 1a pp to detect neutralizing antibodies (NtAb) in eight chimpanzees and four humans infected with 1a strains,...
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