Role of Arg115 in the catalytic action of human lysozyme. X-ray structure of His115 and Glu115 mutants.

doi:10.1006/jmbi.1993.1529

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Article

Role of Arg115 in the catalytic action of human lysozyme. X-ray structure of His115 and Glu115 mutants.

Journal of molecular biology - 5 Oct 1993

Harata K, Muraki M, Jigami Y

Abstract excerpt

The structure of modified human lysozymes (HLs), in which Arg115 is replaced by His or Glu, has been investigated by X-ray analysis at 1.77 A resolution. The mutation of the 115th residue by His does not affect the backbone structure as indicated by a root-mean-square deviation (r.m.s.d) of 0.14...

Topics

Arginine
Binding Sites
Catalysis
Crystallization
Crystallography, X-Ray
Glutamates
Glutamic Acid
Histidine
Humans
Hydrogen Bonding
Kinetics
Least-Squares Analysis
Models, Molecular
Muramidase
Mutation
Protein Conformation

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