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Article

Evidence for difference in the roles of two cysteine residues involved in disulfide bond formation in the folding of human lysozyme.

The Journal of biological chemistry - 5 May 1990

Taniyama Y, Yamamoto Y, Kuroki R, Kikuchi M

Abstract excerpt

Human lysozyme is made up of 130 amino acid residues and has four disulfide bonds at Cys6-Cys128, Cys30-Cys116, Cys65-Cys81, and Cys77-Cys95. Our previous results using the Saccharomyces cerevisiae secretion system indicate that the individual disulfide bonds of human lysozyme have different functions in the correct in vivo folding and enzymatic activity of the protein (Taniyama, Y., Yamamoto, Y., Nakao, M.,...

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PMID: 2110167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Evidence for difference in the roles of two cysteine residues involved in disulfide bond formation in the folding of human lysozyme.PMID 2110167Read ↗

Indication of possible post-translational formation of disulphide bonds in the beta-sheet domain of human lysozyme.Semantic proximity Read ↗

Crystal structure of a mutant human lysozyme with a substituted disulfide bond.Semantic proximity Read ↗

Oxidative folding of human lysozyme: effects of the loss of two disulfide bonds and the introduction of a calcium-binding site.Semantic proximity Read ↗

Secretion in yeast of mutant human lysozymes with and without glutathione bound to cysteine 95.Semantic proximity Read ↗

Analyses of native disulfide bond formations in the early stage of the folding process in mutant lysozymes where the long-range interactions in the denatured state were modulated.Semantic proximity Read ↗

Accelerated secretion of human lysozyme with a disulfide bond mutation.Semantic proximity Read ↗

Folding mechanism of mutant human lysozyme C77/95A with increased secretion efficiency in yeast.Semantic proximity Read ↗

Effect of W62G mutation of hen lysozyme on the folding in vivo.Semantic proximity Read ↗

Occurrence of S-(1,2-dicarboxyethyl)-cysteine at position 77 in mutant human lysozyme secreted by Saccharomyces cerevisiae.Semantic proximity Read ↗

The transition state in the folding-unfolding reaction of four species of three-disulfide variant of hen lysozyme: the role of each disulfide bridge.Semantic proximity Read ↗

Analysis of the early stage of the folding process of reduced lysozyme using all lysozyme variants containing a pair of cysteines.Semantic proximity Read ↗

Evidence for an initiation site for hen lysozyme folding from the reduced form using its dissected peptide fragments.Semantic proximity Read ↗

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