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Article

A large displacement of the SXN motif of Cys115-modified penicillin-binding protein 5 from Escherichia coli.

The Biochemical journal - 15 Nov 2005

Nicola George, Fedarovich Alena, Nicholas Robert A, Davies Christopher

Abstract excerpt

Penicillin-binding proteins (PBPs), which are the lethal targets of beta-lactam antibiotics, catalyse the final stages of peptidoglycan biosynthesis of the bacterial cell wall. PBP 5 of Escherichia coli is a D-alanine CPase (carboxypeptidase) that has served as a useful model to elucidate the catalytic mechanism of low-molecular-mass PBPs. Previous studies have shown that modification of Cys115 with a variety of...

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Identifiers

PMID: 16038617
DOI: 10.1042/BJ20050449
PMCID: PMC1317664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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