Article
Cysteine-string protein increases the calcium sensitivity of neurotransmitter exocytosis in Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 2000
Dawson-Scully K, Bronk P, Atwood H L, Zinsmaier K E
Abstract excerpt
Previous studies suggest that the vesicular cysteine-string protein (CSP) may modulate presynaptic Ca(2+) channel activity in fast neurotransmitter release. To test this hypothesis, we analyzed the dynamics of presynaptic Ca(2+) ion influx with the Ca(2+) indicator fluo-4 AM at csp mutant neuromuscular junctions of Drosophila. From 24 to 30 degrees C, stimulus-evoked, relative presynaptic Ca(2+) signals were...
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