Article
External Ca2+ dependency of synaptic transmission in drosophila synaptotagmin I mutants.
Journal of neurophysiology - 1 Aug 2005
Okamoto Tomonori, Tamura Takuya, Suzuki Kazuhiro, Kidokoro Yoshiaki
Abstract excerpt
To resolve some of differences in reports on the function of Synaptotagmin I (Syt I), we re-examined synaptic transmission at the neuromuscular junction of Drosophila embryos that have mutations in the Syt I gene (syt I). Two major questions addressed were which Ca2+ binding domain, C2A or C2B, sense Ca2+ and is Syt I a negative regulator of spontaneous vesicle fusion. Synaptic currents were induced by nerve...
Topics
- Animals
- Animals, Genetically Modified
- Calcimycin
- Calcium
- Calcium-Binding Proteins
- Dose-Response Relationship, Drug
- Dose-Response Relationship, Radiation
- Drosophila
- Electric Stimulation
- Embryo, Nonmammalian
- Evoked Potentials
- Ionomycin
- Ionophores