Article
Apparent genetic difference between hypothyroid patients with blocking-type thyrotropin receptor antibody and those without, as shown by restriction fragment length polymorphism analyses of HLA-DP loci.
The Journal of clinical endocrinology and metabolism - 1 Sept 1993
Inoue D, Sato K, Sugawa H, Akamizu T, Maeda M, Inoko H, Tsuji K, Mori T
Abstract excerpt
HLA types in Japanese patients with primary hypothyroidism were analyzed to see whether those with blocking-type TSH receptor antibody (TSH-R BAb M) differed genetically from those with idiopathic myxedema (IM). HLA typings of -A, -B, -C, -DR, and -DQ (73 antigens) were performed serologically, a...
Topics
- Adult
- Aged
- Autoantibodies
- Autoimmune Diseases
- Female
- Graves Disease
- HLA Antigens
- HLA-DP Antigens
- HLA-DP beta-Chains
- Humans
- Hypothyroidism
- Immunoglobulins, Thyroid-Stimulating
- Japan
- Male