Article
A strong association between thyrotropin receptor-blocking antibody-positive atrophic autoimmune thyroiditis and HLA-DR8 and HLA-DQB1*0302 in Koreans.
The Journal of clinical endocrinology and metabolism - 1 Sept 1993
Cho B Y, Chung J H, Shong Y K, Chang Y B, Han H, Lee J B, Lee H K, Koh C S
Abstract excerpt
We investigated whether the associations between HLA alleles of patients with autoimmune hypothyroidism varied according to the presence or absence of TSH receptor-blocking antibody (TRBab). We analyzed the HLA-A, -B, -C, and -DR antigens by serotyping and the DQA1 and DQB1 genes using both enzym...
Topics
- Adult
- Alleles
- Autoantibodies
- Base Sequence
- Female
- Gene Frequency
- HLA-C Antigens
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DR Serological Subtypes
- Humans
- Immunoglobulins, Thyroid-Stimulating
- Korea
- Male