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Article

Similarities and differences in interactions of thyroid stimulating and blocking autoantibodies with the TSH receptor.

Journal of molecular endocrinology - 1 Oct 2012

Núñez Miguel Ricardo, Sanders Jane, Sanders Paul, Young Stuart, Clark Jill, Kabelis Katarzyna, Wilmot Jane, Evans Michele, Roberts Emma, Hu Xiaoling, Furmaniak Jadwiga, Rees Smith Bernard

Abstract excerpt

Binding of a new thyroid-stimulating human monoclonal autoantibody (MAb) K1-18 to the TSH receptor (TSHR) leucine-rich domain (LRD) was predicted using charge-charge interaction mapping based on unique complementarities between the TSHR in interactions with the thyroid-stimulating human MAb M22 or the thyroid-blocking human MAb K1-70. The interactions of K1-18 with the TSHR LRD were compared with the interactions...

Topics

Animals
Antibodies, Monoclonal
Autoantibodies
Binding Sites, Antibody
CHO Cells
Cricetinae
Crystallography, X-Ray
Cyclic AMP
Humans
Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Protein Conformation

Receptors, Thyrotropin

Source

Identifiers

PMID: 22829655
DOI: 10.1530/JME-12-0040

Genes

TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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