Article
[Variable-regions of immunoglobulin H-chain genes encoding anti-TSH receptor antibodies].
Nihon rinsho. Japanese journal of clinical medicine - 1 Apr 1994
Matsuda F
Abstract excerpt
We have established EBV-transformed human B cell clones producing monoclonal anti-TSH receptor antibodies from two patients with Graves' disease. We then isolated and characterized immunoglobulin VH genes of 5 B cell clones with the TBII activity and 4 B cell clones with the TSAb activity. We found that VH gene families used in the 5 TBII clones were all VH-III, while those of the 4 TSAb clones were diverse,...
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