[Anti-thyrotropin (TSH) receptor antibody binding epitopes of TSH receptor: site-directed mutagenesis approach].

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Article

[Anti-thyrotropin (TSH) receptor antibody binding epitopes of TSH receptor: site-directed mutagenesis approach].

Nihon rinsho. Japanese journal of clinical medicine - 1 Apr 1994

Akamizu T, Kosugi S, Kohn L D, Mori T

Abstract excerpt

Anti-TSH receptor antibodies are thought to be involved in the expression of autoimmune thyroid diseases, especially Graves' disease and idiopathic myxedema. Cloning of TSH receptor gene allowed us to study aspects of its structure and function at the molecular level, including autoantibody-bindi...

Topics

Amino Acid Sequence
Autoantibodies
Binding Sites, Antibody
Epitopes
Graves Disease
Humans
Immunoglobulins, Thyroid-Stimulating
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Receptors, Thyrotropin

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Open in PubMed

Identifiers

PMID: 7515117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7515117-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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