Article
C to T nucleotide substitution in codon 713 of amyloid precursor protein gene not found in 86 unrelated schizophrenics from multiplex families.
American journal of medical genetics - 1 May 1993
Coon H, Hoff M, Holik J, Delisi L E, Crowe T, Freedman R, Shields G, Boccio A M, Lerman M, Gershon E S
Abstract excerpt
Jones et al. Nature Genet 1:306-309, [1992] recently detected a C to T nucleotide transition (codon 713) in a highly conserved region of the beta-amyloid precursor gene in a single case of schizophrenia. Although the sequence variant may be a natural polymorphism, it is crucial to determine whether the mutation might be present in a small subset of schizophrenics. We isolated DNA from 86 unrelated chronic...
Topics
- Amyloid beta-Protein Precursor
- Base Sequence
- Chronic Disease
- Codon
- Cytosine
- DNA
- Genetic Linkage
- Genetic Markers
- Humans
- Lod Score
- Molecular Sequence Data